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KMID : 0357919850190010045
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Korean Journal of Pathology
1985 Volume.19 No. 1 p.45 ~ p.50
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Frozen Section -Indications, limitations, and accuracy-
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Abstract
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The rapid frozen section method is a means of intraoperative pathological diagnosis,
first introduces by Welch in 1891 and developed as a diagnostic tool by Cullen, Wilson,
MacCarty et al.
This method serves useful purposes, such as determining the malignancy or
benignancy of a suspected lesion, determining the adequacy of a biopsy of a suspected
lesion, confirming the presence or absence of metabasis, and identifying small structures.
But it bears many disadvantages, the most of which is the danger of incorrect
diagnosis.
We studied the indications, the limitations and the accuracy of the frozen section
method and the materials studied was total cases of frozen section during recent 5
years.
The overall accuracy of the frozen section diagnosis of 1, 603 cases was 96.2% with
0.3% of false positive, 3, 5% of false negative and 2.871 of incorrect histological
diagnoses or grading errors.
The tissues submitted for frozen section were lymph node, breast, gastrointestinal
tract and soft tissue in decreasing order of frequency. The false positive cases were
four in number, while the false negative cases were 53, one third of which were the
misdiagnoses of the presence of ganglion cells in Hirschsprung's disease.
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